Acyclovir is an antiviral medication that is primarily used to treat infections caused by the herpes simplex virus, including genital herpes, cold sores, and shingles. It can be taken orally or administered intravenously. When considering any medication, it is important to be aware of potential drug interactions that could affect its effectiveness or cause adverse effects.

According to the sources provided, there are several drugs that may interact with acyclovir. These interactions can vary from moderate to severe, and it is crucial to consult with a healthcare professional before starting or stopping any medications. Here are some notable drug interactions with acyclovir:

1. Probenecid: Probenecid is a medication used to treat gout. It can increase the levels of acyclovir in the body, potentially leading to an increased risk of side effects [2].

2. Zidovudine: Zidovudine is an antiviral medication used to treat HIV infection. When taken together with acyclovir, there may be an increased risk of side effects, such as dizziness, drowsiness, and confusion [2].

3. Nephrotoxic drugs: Acyclovir can potentially cause kidney damage, especially when used in high doses or for a prolonged period. Taking acyclovir with other nephrotoxic drugs, such as aminoglycoside antibiotics or nonsteroidal anti-inflammatory drugs (NSAIDs), may further increase the risk of kidney damage [3].

4. Interferon: Interferon is a medication used to treat viral infections and certain types of cancer. Combining acyclovir with interferon may increase the risk of kidney damage [3].

5. Other antiviral medications: Taking acyclovir with other antiviral medications, such as valacyclovir or famciclovir, may increase the risk of side effects [1].

It is important to note that this is not an exhaustive list of all possible drug interactions with acyclovir. Other medications, including over-the-counter drugs, herbal supplements, and vitamins, may also interact with acyclovir. Therefore, it is crucial to inform your healthcare provider about all the medications you are currently taking before starting acyclovir.

In conclusion, acyclovir can interact with various medications, including probenecid, zidovudine, nephrotoxic drugs, interferon, and other antiviral medications. It is essential to consult with a healthcare professional to determine the safety and efficacy of combining acyclovir with other medications [1][2][3].

Sources:
[1] DrugPatentWatch. (n.d.). Acyclovir - Tradename: Acyclovir. Retrieved from https://www.drugpatentwatch.com/p/tradename/ACYCLOVIR
[2] Mayo Clinic. (2021). Acyclovir (Oral Route, Intravenous Route) - Before Using. Retrieved from https://www.mayoclinic.org/drugs-supplements/acyclovir-oral-route-intravenous-route/before-using/drg-20068393
[3] WebMD. (n.d.). Acyclovir Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. Retrieved from https://www.webmd.com/drugs/2/drug-941/acy