Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. The medication works by inhibiting the HMG-CoA reductase enzyme, which is responsible for cholesterol synthesis in the liver [1]. There is no evidence that suggests that Lipitor decreases the potency of herbal remedies. However, there is a possibility of drug interactions between Lipitor and certain herbal remedies that could lead to adverse effects.

According to a study published in the National Center for Biotechnology Information, some herbal remedies may interact with Lipitor by inhibiting or inducing the CYP3A4 enzyme, which is responsible for the metabolism of atorvastatin [2]. For example, St. John's Wort, a herbal remedy used to treat depression, has been shown to induce the CYP3A4 enzyme, which could lead to a decrease in the effectiveness of Lipitor [2]. On the other hand, grapefruit juice, which is not an herbal remedy but a fruit juice, has been shown to inhibit the CYP3A4 enzyme, leading to an increase in the concentration of atorvastatin in the blood, which could increase the risk of adverse effects [3].

Therefore, it is important to consult with a healthcare provider before taking any herbal remedies while on Lipitor to avoid potential drug interactions. The healthcare provider may advise on the appropriate dosages and timing of the herbal remedies to avoid any potential adverse effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036014/
[3] https://www.medsafe.govt.nz/profs/PUArticles/March2014StatinsAndCYPInteractions.htm