Based on the available information, it is possible for diet and lifestyle changes to potentially reduce the effects of Lipitor on the liver. Lipitor, also known as atorvastatin, is a medication used to treat high cholesterol levels by inhibiting the HMG-CoA reductase enzyme, which plays a crucial role in the production of cholesterol in the liver [1][2].

While Lipitor is generally considered safe and effective, it can have side effects, including liver damage [1][2]. However, it is important to note that the liver damage caused by Lipitor is usually mild and reversible [2].

Diet and lifestyle changes can play a significant role in managing high cholesterol levels and reducing the need for medication or its dosage [3]. These changes include:

1. Eating a heart-healthy diet: This includes limiting the intake of saturated and trans fats, cholesterol, and refined sugars while increasing the consumption of fruits, vegetables, whole grains, lean proteins, and healthy fats [3].
2. Regular exercise: Engaging in regular physical activity can help lower cholesterol levels and improve overall cardiovascular health [3].
3. Maintaining a healthy weight: Excess body weight can contribute to high cholesterol levels, so maintaining a healthy weight through diet and exercise is essential [3].
4. Avoiding tobacco and limiting alcohol: Both tobacco and excessive alcohol consumption can increase cholesterol levels and the risk of liver damage [3].

While these lifestyle changes can help reduce cholesterol levels and the need for medication, it is essential to consult with a healthcare provider before making any changes to medication or lifestyle [3].

In summary, diet and lifestyle changes can potentially reduce the effects of Lipitor on the liver by lowering cholesterol levels and reducing the need for medication or its dosage. However, it is crucial to consult with a healthcare provider before making any changes to medication or lifestyle.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] <https://www.ncbi.nlm.nih.gov/books/NBK430779/>
[3] <https://www.uptodate.com/contents/high-cholesterol-and-lipid-treatment-options-beyond-the-basics/print>