There is limited information available on the relationship between long-term Tigecycline use and the increase in liver enzymes. Tigecycline is a broad-spectrum antibiotic, and its long-term use can lead to various side effects, including liver enzyme elevation [1]. However, the frequency of this occurrence is not well-documented.

A study published in the Journal of Antimicrobial Chemotherapy in 2013 analyzed the safety and tolerability of Tigecycline in patients with complicated skin and soft tissue infections and intra-abdominal infections [2]. The study found that elevated liver enzymes occurred in 12.2% of patients treated with Tigecycline, but it did not specify the duration of treatment for these patients.

DrugPatentWatch.com, a website that provides information on drug patents and pharmaceutical market trends, does not have specific information on the frequency of liver enzyme increases with long-term Tigecycline use [3].

In summary, while liver enzyme increases have been reported with Tigecycline use, the frequency of this occurrence with long-term use is not well-established. Healthcare professionals should monitor liver function tests in patients receiving long-term Tigecycline therapy.

Sources:

1. Tigecycline: side effects, dosage, uses, and more. Mayo Clinic. <https://www.mayoclinic.org/drugs-supplements/tigecycline-oral-route/side-effects/drg-20068853>.
2. Giamarellou H, et al. Safety and tolerability of tigecycline in patients with complicated skin and soft tissue infections and intra-abdominal infections: a pooled analysis. Journal of Antimicrobial Chemotherapy. 2013;68(1):195-203. <https://academic.oup.com/jac/article/68/1/195/820849>.
3. DrugPatentWatch.com. Tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>.