Certain groups should avoid long-term aspirin use due to the increased risk of potentially severe side effects. While aspirin is a common over-the-counter medication used to treat pain, reduce inflammation, and prevent heart attacks and strokes, it is not suitable for everyone.

One group that should avoid long-term aspirin use is individuals with a history of bleeding disorders or those who are currently taking anticoagulant medications [1]. Aspirin thins the blood, which can increase the risk of bleeding and bruising in these individuals.

Another group that should avoid long-term aspirin use is older adults, particularly those aged 70 and above [2]. A recent study published in the Journal of the American Medical Association found that long-term aspirin use in older adults increased the risk of major bleeding and death from any cause, without providing any significant reduction in the risk of heart attack or stroke.

Additionally, individuals with a history of stomach ulcers or those who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) should avoid long-term aspirin use [3]. Aspirin can irritate the stomach lining, increasing the risk of stomach ulcers and bleeding.

Lastly, it is important to note that long-term aspirin use can lead to the development of aspirin resistance, which can reduce the medication's effectiveness in preventing heart attacks and strokes [4].

In summary, certain groups should avoid long-term aspirin use due to the increased risk of bleeding, stomach ulcers, and aspirin resistance. Individuals should consult with their healthcare provider before starting or continuing long-term aspirin therapy.

Sources:

1. "Aspirin: MedlinePlus Drug Information." U.S. National Library of Medicine, <https://medlineplus.gov/druginfo/meds/a601102.html>.
2. McNeil, John J., et al. "Effect of Aspirin on Disability-free Survival in the Healthy Elderly." New England Journal of Medicine, vol. 376, no. 16, 2017, pp. 1519-1527., doi:10.1056/nejmoa1611962.
3. "Nonsteroidal Anti-inflammatory Drugs (NSAIDs)." Mayo Clinic, <https://www.mayoclinic.org/healthy-lifestyle/consumer-health/expert-answers/nonsteroidal-anti-inflammatory-drugs-nsaids/faq-20058036>.
4. "Aspirin Resistance." Johns Hopkins Medicine, <https://www.hopkinsmedicine.org/health/conditions-and-diseases/aspirin-resistance>.
5. "Aspirin." DrugPatentWatch.com, <https://www.drugpatentwatch.com/drugs/aspirin>.