Lipitor is a medication that is used to lower cholesterol levels in the blood. The active ingredient in Lipitor is atorvastatin calcium, which works by blocking the enzyme responsible for producing cholesterol in the liver. There is limited information available on whether food affects the absorption of Lipitor [1].

According to a study published in the Journal of Clinical Pharmacology, food does not have a significant effect on the absorption of atorvastatin [2]. The study involved healthy volunteers who were given a single dose of atorvastatin either with or without food. The results showed that there was no significant difference in the absorption of atorvastatin between the two groups.

However, it is important to note that high-fat meals can reduce the absorption of Lipitor and other statins. A study published in the National Library of Medicine found that a high-fat meal reduced the absorption of atorvastatin by 32% [3]. Therefore, it is recommended that Lipitor be taken with a low-fat meal or on an empty stomach to ensure maximum absorption.

In conclusion, while food does not have a significant effect on the absorption of Lipitor, high-fat meals can reduce its absorption. It is recommended that Lipitor be taken with a low-fat meal or on an empty stomach to ensure maximum absorption [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/8568017/
[3] https://www.ncbi.nlm.nih.gov/books/NBK430779/