Aspirin overdose can have detrimental effects on the kidneys. The kidneys are particularly vulnerable to aspirin toxicity due to the drug's impact on renal blood flow and the kidneys' role in excreting the medication. Overdosing on aspirin can lead to acute kidney injury, which is characterized by a sudden decrease in kidney function. This condition can manifest as electrolyte imbalances, decreased urine output, and in severe cases, kidney failure. Additionally, aspirin overdose can cause interstitial nephritis, a kidney disorder characterized by inflammation in the spaces between kidney tubules. It is crucial to seek immediate medical attention if an aspirin overdose is suspected to prevent serious kidney damage and other potential complications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://www.mountsinai.org/health-library/poison/aspirin-overdose
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874173/