Advil is a brand name for the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. It is used to treat pain, fever, and inflammation. While Advil is generally safe when used as directed, there are potential long-term side effects associated with its use.

One potential side effect of long-term Advil use is gastrointestinal problems. NSAIDs can irritate the lining of the stomach and increase the risk of ulcers and bleeding [2]. This risk is higher in people who take high doses of Advil or who use it for a long time. To reduce this risk, it is recommended to take the lowest effective dose of Advil for the shortest possible time [3].

Another potential long-term side effect of Advil use is kidney damage. NSAIDs can reduce blood flow to the kidneys and cause damage over time [2]. This risk is higher in people who have pre-existing kidney problems or who take high doses of Advil for a long time. It is important to talk to a healthcare provider before taking Advil if you have kidney problems [3].

Advil can also interact with other medications and increase the risk of side effects [1]. It is important to talk to a healthcare provider or pharmacist before taking Advil with other medications.

In conclusion, while Advil is generally safe when used as directed, there are potential long-term side effects associated with its use. These include gastrointestinal problems and kidney damage. To reduce the risk of these side effects, it is recommended to take the lowest effective dose of Advil for the shortest possible time and to talk to a healthcare provider before taking Advil with other medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://adf.org.au/drug-facts/ibuprofen/
[3] https://www.goodrx.com/advil/advil-side-effects