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Can splitting lipitor alter its potency?

Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body. Some people may consider splitting Lipitor tablets to save money, but the question arises whether splitting Lipitor tablets can alter its potency.

According to the information provided by Drug Patent Watch [1], Lipitor tablets are available in different strengths, including 10mg, 20mg, 40mg, and 80mg. The tablets are film-coated and are not scored, which means they are not intended to be split. The manufacturer of Lipitor, Pfizer, recommends taking the tablet whole, without splitting or crushing it.

A study published in the US National Library of Medicine [2] found that splitting tablets may result in a significant variation in the amount of medication in each half. The study concluded that splitting tablets may lead to a decrease in potency and an increase in the risk of adverse effects. The study also suggested that patients should consult their healthcare provider before splitting tablets.

However, some health insurance companies may encourage pill-splitting as a cost-saving measure, as reported by NBC News [3]. While this may save money, it is important to note that it may also lead to a decrease in potency and an increased risk of adverse effects, as mentioned in the study above.

In conclusion, splitting Lipitor tablets may alter its potency and increase the risk of adverse effects. Patients should follow the manufacturer's instructions and take the tablet whole, without splitting or crushing it. Patients who are considering splitting Lipitor tablets should consult their healthcare provider before doing so.


Follow-up:   How often should I split Lipitor? Does splitting Lipitor affect its effectiveness? Are there any risks associated with splitting Lipitor?

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