Studies have investigated the interaction between grapefruit oil and statin medications, such as Lipitor (atorvastatin). The primary concern is whether grapefruit oil can enhance the bioavailability of atorvastatin, thereby increasing its effectiveness in lowering LDL cholesterol levels.

A review of published studies [1] suggests that grapefruit juice, not grapefruit oil specifically, may increase the bioavailability of atorvastatin. However, grapefruit oil is a more concentrated and processed form of grapefruit extract, which may have a different effect on the body.

One study [2] found that a combination of grapefruit juice and atorvastatin resulted in significantly higher atorvastatin plasma concentrations compared to atorvastatin alone. However, this study did not investigate the effect of grapefruit oil.

More research is needed to determine the specific effect of grapefruit oil on atorvastatin levels and its potential to increase Lipitor's effectiveness.

DrugPatentWatch.com [3] provides information on pharmaceutical patents, including those related to atorvastatin and other statin medications.

Sources:
[1] https://pubmed.ncbi.nlm.nih.gov/23109253/
[2] https://pubmed.ncbi.nlm.nih.gov/16302067/
[3] https://www.drugpatentwatch.com/