Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat pain, fever, and inflammation. It is also used for long-term prevention of heart attacks, strokes, and blood clotting disorders. The drug works by blocking the production of certain chemicals in the body that cause inflammation, pain, and blood clots.

According to [1], aspirin has been used for over a century and is generally considered safe for long-term use. However, it is important to note that like any medication, aspirin can have side effects. Some common side effects of aspirin include stomach pain, heartburn, nausea, and bleeding. Long-term use of aspirin can also increase the risk of gastrointestinal bleeding and ulcers.

The Mayo Clinic [2] recommends that people who are considering taking aspirin for long-term prevention of heart attacks or strokes should talk to their doctor first. The decision to take aspirin should be based on individual risk factors and medical history. The Mayo Clinic also advises against taking aspirin if you have a bleeding disorder, a history of stomach ulcers, or are allergic to aspirin.

A study published in the US National Library of Medicine [3] found that low-dose aspirin therapy can be used safely for long-term prevention of cardiovascular disease in patients who are at high risk. However, the study also noted that the benefits of aspirin therapy should be weighed against the risks of bleeding and other side effects.

In conclusion, aspirin is generally considered safe for long-term use, but like any medication, it can have side effects. People who are considering taking aspirin for long-term prevention of heart attacks or strokes should talk to their doctor first and weigh the benefits against the risks.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086018/