Lipitor, also known as atorvastatin, is a medication that is used to lower cholesterol levels in the blood. The drug works by inhibiting the enzyme HMG-CoA reductase, which is responsible for the production of cholesterol in the liver [1]. While there is no direct evidence that suggests Lipitor can disrupt pancreatic enzyme levels, studies have shown that it may cause pancreatitis, which is inflammation of the pancreas [2][3].

Pancreatitis can occur as a result of elevated levels of triglycerides in the blood, which can be a side effect of Lipitor use. In some cases, pancreatitis can lead to the development of pancreatic insufficiency, which is a condition where the pancreas is unable to produce enough digestive enzymes to break down food [2]. However, it is important to note that not all cases of pancreatitis are caused by Lipitor, and the condition can also be caused by other factors such as gallstones, alcohol consumption, and certain medications [3].

In conclusion, while there is no direct evidence that suggests Lipitor can disrupt pancreatic enzyme levels, it may cause pancreatitis, which can lead to the development of pancreatic insufficiency. Patients taking Lipitor should be aware of the potential side effects and should speak with their healthcare provider if they experience any symptoms of pancreatitis, such as abdominal pain, nausea, and vomiting [2][3].

Sources:
[1] DrugPatentWatch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Circulation Research. (2018). Atorvastatin-Induced Pancreatitis: A Case Report and Review of Literature. Retrieved from https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.312782
[3] National Center for Biotechnology Information. (2021). Statin-Induced Pancreatitis: A Comprehensive Review of the Literature. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061391/