Mixing alcohol and Advil frequently can have harmful effects on the body. Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain, inflammation, and fever. Alcohol, on the other hand, is a depressant that can impair cognitive and motor function. When these two substances are combined, they can have a negative impact on the liver and gastrointestinal tract [3].

According to Drug Patent Watch [1], there is no known interaction between alcohol and Advil that would make it unsafe to take them together. However, this does not mean that it is safe to mix them frequently. Mixing alcohol and Advil can increase the risk of stomach bleeding, ulcers, and liver damage [2].

The combination of alcohol and Advil can also lead to dehydration, which can exacerbate the effects of alcohol and increase the risk of liver damage. In addition, taking Advil with alcohol can increase the risk of gastrointestinal bleeding, especially if you have a history of ulcers or other gastrointestinal issues [3].

It is important to note that the effects of mixing alcohol and Advil can vary depending on the individual. Some people may be more susceptible to the negative effects of this combination, especially if they have a history of liver or gastrointestinal problems. It is always best to consult with a healthcare provider before mixing alcohol and Advil or any other medications [3].

In conclusion, while there is no known interaction between alcohol and Advil that would make it unsafe to take them together, it is not recommended to mix them frequently. The combination of alcohol and Advil can increase the risk of stomach bleeding, ulcers, and liver damage. It is always best to consult with a healthcare provider before mixing alcohol and Advil or any other medications [3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ALCOHOL
[2] https://www.goodrx.com/classes/nsaids/mixing-with-alcohol
[3] https://www.medicalnewstoday.com/articles/mixing-ibuprofen-and-alcohol