Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the blood. According to the sources provided, there is no evidence to suggest that higher doses of Lipitor require a longer adjustment time.

The first source, Drug Patent Watch [1], provides information on the patent status and expiration of Lipitor. While this source does not provide information on the adjustment time for Lipitor, it does indicate that the drug has been widely prescribed and has been available in various dosages.

The second source, a 2007 article from American Family Physician [2], provides an overview of the use of statins, including Lipitor, in managing cholesterol levels. The article notes that the effectiveness of statins is related to the dose, with higher doses generally producing greater reductions in cholesterol levels. However, the article does not mention any differences in the adjustment time for different doses of Lipitor.

The third source, a chapter from a medical textbook on lipid disorders [3], discusses the use of atorvastatin in managing high cholesterol. The chapter notes that the drug is effective at reducing cholesterol levels and is generally well-tolerated, with most side effects being mild and temporary. However, the chapter does not provide any information on the adjustment time for different doses of Lipitor.

In summary, while the sources provided do not specifically address the question of whether higher doses of Lipitor require a longer adjustment time, there is no evidence to suggest that this is the case. It is important for patients to follow their healthcare provider's instructions regarding dosage and to report any side effects or concerns promptly.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.aafp.org/pubs/afp/issues/2007/0515/p1487.html
[3] https://www.ncbi.nlm.nih.gov/books/NBK430779/