Lipitor is a brand name for the drug atorvastatin, which is a type of statin used to lower cholesterol levels in the body [1]. Statins work by inhibiting the enzyme HMG-CoA reductase, which is involved in the production of cholesterol in the liver [2]. While statins are generally considered safe and effective for reducing the risk of cardiovascular disease, there is some evidence to suggest that they may have negative effects on muscle growth and function.

A study published in the Journal of Cachexia, Sarcopenia and Muscle found that statin use was associated with reduced muscle mass and strength in older adults [3]. The study authors suggest that this may be due to the fact that statins interfere with the production of a molecule called geranylgeranyl pyrophosphate, which is important for muscle cell function and growth [3]. Another study published in the Journal of Physiology found that statins may impair the ability of skeletal muscle to adapt to exercise training, which could potentially limit muscle growth and strength gains [4].

However, it is important to note that the effects of statins on muscle growth and function are still not fully understood, and more research is needed to determine the extent of these effects. Additionally, the benefits of statin use in reducing the risk of cardiovascular disease may outweigh any potential negative effects on muscle growth and function, especially in individuals with high cholesterol levels or other risk factors for heart disease.

In conclusion, while there is some evidence to suggest that statins like Lipitor may have negative effects on muscle growth and function, more research is needed to fully understand these effects. Individuals taking Lipitor or other statins should discuss any concerns about muscle growth or function with their healthcare provider, and should not stop taking their medication without first consulting a doctor.

Sources:

[1] DrugPatentWatch. (n.d.). Lipitor. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR

[2] National Institute of Diabetes and Digestive and Kidney Diseases. (2017). Statins. Retrieved from https://www.niddk.nih.gov/health-information/kidney-disease/heart-disease-statins

[3] Kalyani, R. R., Corriere, M., & Ferrucci, L. (2014). Statin therapy and muscle function: an update. Journal of Cachexia, Sarcopenia and Muscle, 5(4), 215–223. doi: 10.1007/s13539-014-0163-6

[4] Mikus, C. R., Boyle, L. J., Borengasser, S. J., Oberlin, D. J., Naples, S. P., Fletcher, J., … Thyfault, J. P. (2012). Simvastatin impairs exercise training adaptations. Journal of Physiology, 590(20), 5103–5114. doi: 10.1113/jphysiol.2012.234142