Combining grapefruit juice and Lipitor (atorvastatin) can increase the risk of side effects, such as muscle damage, liver damage, and kidney failure. Lipitor is a statin medication that is used to lower cholesterol levels in the blood, while grapefruit juice contains compounds that can interfere with the metabolism of the drug in the body [1][2].

The liver enzyme CYP3A4 is responsible for breaking down Lipitor in the body. Grapefruit juice contains compounds called furanocoumarins that inhibit this enzyme, leading to higher levels of the drug in the bloodstream. This can increase the risk of side effects, particularly muscle damage, which can cause weakness, pain, and even kidney failure in severe cases [2][3].

It is recommended to avoid consuming grapefruit juice or grapefruit products while taking Lipitor. If you are taking Lipitor and have consumed grapefruit juice, it is important to monitor for any signs of muscle pain or weakness and contact your healthcare provider if you experience any symptoms [2][3].

In conclusion, combining grapefruit juice and Lipitor can increase the risk of side effects, particularly muscle damage, liver damage, and kidney failure. It is recommended to avoid consuming grapefruit juice or grapefruit products while taking Lipitor to minimize the risk of these side effects [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/classes/statins/why-cant-i-have-grapefruit-with-my-statin
[3] https://ro.co/health-guide/lipitor-and-grapefruit/