Lyrica is a medication used to treat various conditions such as epilepsy, neuropathic pain, and anxiety disorders. While Lyrica has been found to be effective in treating these conditions, it is important to understand the potential side effects of the drug, particularly on the cardiovascular system.

According to Drug Patent Watch [1], Lyrica's label includes a warning about the potential for cardiovascular events such as heart failure, arrhythmia, and hypertension. The label also states that patients with a history of cardiovascular disease may be at increased risk for these events.

A study published in the Journal of Clinical Psychopharmacology [2] found that Lyrica may cause changes in heart rate and blood pressure in some patients. The study reported that these changes were generally mild and resolved on their own without any intervention.

Another study published in the journal Cardiovascular Diabetology [3] found that Lyrica may increase the risk of cardiovascular disease in patients with type 2 diabetes. The study reported that patients taking Lyrica had a higher risk of developing cardiovascular disease compared to those not taking the drug.

In summary, while Lyrica has been found to be effective in treating various conditions, it is important to be aware of the potential side effects of the drug on the cardiovascular system. Patients with a history of cardiovascular disease may be at increased risk for cardiovascular events while taking Lyrica. Additionally, Lyrica may cause changes in heart rate and blood pressure in some patients, and may increase the risk of cardiovascular disease in patients with type 2 diabetes. Patients taking Lyrica should be closely monitored for any cardiovascular symptoms or changes in heart rate or blood pressure.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] https://pubmed.ncbi.nlm.nih.gov/21644108/
[3] https://cardiab.biomedcentral.com/articles/10.1186/s12933-022-01610-9