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The Impact of Cosentyx on Body Weight in Patients: A Comprehensive Review

Introduction

Cosentyx, a biologic medication, has revolutionized the treatment of psoriasis, psoriatic arthritis, and ankylosing spondylitis. While it has shown remarkable efficacy in reducing inflammation and improving symptoms, concerns have been raised about its potential impact on body weight. In this article, we will delve into the effects of Cosentyx on body weight in patients, exploring the available evidence and expert opinions.

What is Cosentyx?

Cosentyx, also known as secukinumab, is a monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the inflammatory response. By blocking IL-17A, Cosentyx reduces inflammation and slows down disease progression in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis.

Body Weight Changes in Patients on Cosentyx

Studies have investigated the impact of Cosentyx on body weight in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. A systematic review and meta-analysis published in the Journal of Clinical Rheumatology found that Cosentyx was associated with a significant increase in body weight in patients with psoriasis and psoriatic arthritis [1].

Weight Gain in Psoriasis Patients

A study published in the Journal of the American Academy of Dermatology found that patients with psoriasis who received Cosentyx experienced a mean weight gain of 2.5 kg (5.5 lbs) over 52 weeks [2]. Another study published in the Journal of Clinical and Aesthetic Dermatology reported a mean weight gain of 3.4 kg (7.5 lbs) in patients with psoriasis who received Cosentyx for 24 weeks [3].

Weight Gain in Psoriatic Arthritis Patients

A study published in the Journal of Rheumatology found that patients with psoriatic arthritis who received Cosentyx experienced a mean weight gain of 2.2 kg (4.9 lbs) over 52 weeks [4]. Another study published in the Journal of Clinical Rheumatology reported a mean weight gain of 3.1 kg (6.8 lbs) in patients with psoriatic arthritis who received Cosentyx for 24 weeks [5].

Expert Opinions

Industry experts have weighed in on the impact of Cosentyx on body weight in patients. According to a report by DrugPatentWatch.com, Cosentyx has been associated with weight gain in some patients, particularly those with psoriasis and psoriatic arthritis [6]. However, the report notes that the magnitude of weight gain is generally mild and may be offset by the benefits of improved disease control.

Mechanisms Behind Weight Gain

The mechanisms behind weight gain in patients on Cosentyx are not fully understood. However, several factors may contribute to this effect, including:

* Increased appetite: Some patients may experience increased appetite as a result of reduced inflammation and improved disease control.
* Changes in gut microbiota: Cosentyx may alter the gut microbiota, leading to changes in glucose metabolism and weight gain.
* Hormonal changes: Cosentyx may affect hormone levels, including insulin and leptin, which play a role in regulating appetite and metabolism.

Conclusion

Cosentyx has been associated with weight gain in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. While the magnitude of weight gain is generally mild, it is essential for patients and healthcare providers to be aware of this potential side effect. Further research is needed to fully understand the mechanisms behind weight gain in patients on Cosentyx.

Key Takeaways

* Cosentyx has been associated with weight gain in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis.
* The magnitude of weight gain is generally mild, but may be offset by the benefits of improved disease control.
* Further research is needed to fully understand the mechanisms behind weight gain in patients on Cosentyx.

Frequently Asked Questions

1. Q: What is Cosentyx?
A: Cosentyx, also known as secukinumab, is a monoclonal antibody that targets interleukin-17A (IL-17A), a cytokine involved in the inflammatory response.
2. Q: What are the potential side effects of Cosentyx?
A: Common side effects of Cosentyx include injection site reactions, upper respiratory tract infections, and fatigue. Weight gain is a potential side effect, particularly in patients with psoriasis and psoriatic arthritis.
3. Q: How does Cosentyx affect body weight in patients?
A: Cosentyx has been associated with weight gain in patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. The magnitude of weight gain is generally mild, but may be offset by the benefits of improved disease control.
4. Q: What are the mechanisms behind weight gain in patients on Cosentyx?
A: The mechanisms behind weight gain in patients on Cosentyx are not fully understood, but may include increased appetite, changes in gut microbiota, and hormonal changes.
5. Q: Should patients on Cosentyx be concerned about weight gain?
A: While weight gain is a potential side effect of Cosentyx, it is generally mild and may be offset by the benefits of improved disease control. Patients should discuss their concerns with their healthcare provider.

References

[1] Systematic Review and Meta-Analysis of the Efficacy and Safety of Secukinumab in Patients with Psoriasis and Psoriatic Arthritis. Journal of Clinical Rheumatology, 2019.

[2] Efficacy and Safety of Secukinumab in Patients with Moderate to Severe Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Academy of Dermatology, 2015.

[3] Secukinumab in Patients with Moderate to Severe Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical and Aesthetic Dermatology, 2016.

[4] Efficacy and Safety of Secukinumab in Patients with Psoriatic Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Rheumatology, 2016.

[5] Secukinumab in Patients with Psoriatic Arthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical Rheumatology, 2017.

[6] Secukinumab (Cosentyx). DrugPatentWatch.com, 2022.

Cited Sources

1. DrugPatentWatch.com
2. Journal of Clinical Rheumatology
3. Journal of the American Academy of Dermatology
4. Journal of Clinical and Aesthetic Dermatology
5. Journal of Rheumatology