Based on the information available, there is no evidence to suggest that Lipitor, a medication commonly used to treat high cholesterol, works differently when taken without water. Lipitor, also known as atorvastatin, is a type of drug called a statin, which works in the liver to lower cholesterol levels.

The method of administration for Lipitor, as outlined by the manufacturer and the U.S. Food and Drug Administration (FDA), is to be taken orally, typically once a day, with or without food. However, it does not specify that it must be taken with water specifically.

It is important to note that taking medication as directed by the manufacturer and healthcare provider is crucial for ensuring its safety and effectiveness. Deviating from the recommended method of administration, such as not taking a medication with water, could potentially lead to issues such as difficulty swallowing or improper absorption of the drug.

In conclusion, while there is no evidence to suggest that Lipitor works differently when taken without water, it is recommended to follow the instructions provided by the manufacturer and healthcare provider for proper administration.

Sources:

* [Lipitor (atorvastatin) tablets, for oral use. Full Prescribing Information. Pfizer Labs Div Pfizer Inc.](https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/20267s125,20268s123,20269s115lbl.pdf)
* [Atorvastatin (Lipitor) - Drug Patent Watch](https://www.drugpatentwatch.com/drugs/atorvastatin)
* [High Cholesterol Medications (Statins). Mayo Clinic](https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statins/art-20045781)
* [How to Use Atorvastatin (Lipitor). WebMD](https://www.webmd.com/cholesterol-management/how-to-use-atorvastatin-lipitor)
* [Atorvastatin (Oral Route). Mayo Clinic](https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/before-using/drg-20064585)