Yes, aspirin can cause stomach irritation when taken empty-handed, or without food. This is because aspirin is an acidic medication that can irritate the lining of the stomach and cause inflammation, ulcers, and other gastrointestinal problems [1].

When aspirin is taken with food, the stomach's natural defenses are better able to protect against these irritating effects. However, even with food, long-term use of aspirin can still lead to stomach problems [1].

It is important to follow the recommended dosage and instructions for taking aspirin, as well as to consult with a healthcare provider or pharmacist if you have any concerns or questions about potential side effects [2].

In addition, it is worth noting that aspirin is a common medication with a wide range of uses, from pain relief to preventing heart attacks and strokes [3]. However, like all medications, it can have side effects and interactions with other drugs, so it is important to use it safely and responsibly.

Sources:

1. Mayo Clinic. (2021). Aspirin: Uses, side effects, interactions, and dosing. <https://www.mayoclinic.org/drugs-supplements-aspirin/art-20365802>.
2. DrugPatentWatch.com. (n.d.). Aspirin. <https://www.drugpatentwatch.com/drugs/aspirin>.
3. National Institute on Aging. (2021). Aspirin and Heart Disease. <https://www.nia.nih.gov/health/aspirin-and-heart-disease>.