Lipitor is a medication used to lower cholesterol levels in the body. The drug works by inhibiting the enzyme HMG-CoA reductase, which is responsible for producing cholesterol in the liver [1]. According to the Mayo Clinic [2], common side effects of Lipitor include muscle pain and weakness, liver damage, digestive problems, and an increased risk of developing type 2 diabetes. However, these side effects are typically mild and go away once the medication is stopped.

In terms of long-term effects of higher Lipitor dosage, a study published in the Journal of the American College of Cardiology [3] found that high-dose statin therapy (including Lipitor) was associated with a decreased risk of cardiovascular events in patients with established coronary artery disease. However, the study also noted that high-dose statin therapy was associated with an increased risk of developing diabetes mellitus.

Another study published in the Journal of Clinical Lipidology [4] found that high-dose statin therapy (including Lipitor) was associated with an increased risk of developing muscle-related side effects such as myopathy and rhabdomyolysis. The study also noted that the risk of developing these side effects was higher in patients with certain genetic predispositions.

Overall, while high-dose Lipitor therapy may be effective in reducing the risk of cardiovascular events, it is important for patients to be aware of the potential risks and side effects associated with the medication. Patients should always discuss any concerns or questions with their healthcare provider before starting or changing any medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059187/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513499/