Lipitor is a prescription drug that is commonly used to treat high cholesterol. It is a type of statin medication that works by blocking the production of cholesterol in the liver. While Lipitor is an effective medication, it can interact with certain foods and beverages, including citrus juices.

Grapefruit juice is the most well-known citrus juice that can interact with Lipitor. According to a Harvard Health Publishing article [2], grapefruit juice contains compounds that can inhibit the enzymes responsible for breaking down Lipitor in the body. This can cause Lipitor to build up in the bloodstream, leading to an increased risk of side effects. The article recommends avoiding grapefruit juice while taking Lipitor.

Other citrus juices may also interact with Lipitor, although they are not as well-studied as grapefruit juice. According to Healthline [3], orange juice and tangerine juice may also inhibit the enzymes responsible for breaking down Lipitor, leading to increased levels of the drug in the bloodstream. However, the article notes that the effects of these juices are not as significant as those of grapefruit juice.

In conclusion, grapefruit juice is the citrus juice most likely to interact with Lipitor. Other citrus juices, such as orange juice and tangerine juice, may also interact with Lipitor to a lesser extent. Patients taking Lipitor should consult with their healthcare provider about whether they need to avoid citrus juices while taking this medication.

Sources:
[2] https://www.health.harvard.edu/heart-health/grapefruit-juice-and-statins
[3] https://www.healthline.com/health/high-cholesterol/grapefruit-and-statins