Based on the information available, there is no definitive answer to whether Advil (ibuprofen) affects antidepressant absorption. However, it is known that both Advil and antidepressants are metabolized in the liver by enzymes, and thus, they can potentially interact with each other [1].

According to DrugPatentWatch.com, ibuprofen and antidepressants such as fluoxetine, sertraline, and citalopram have different mechanisms of action and are metabolized by different enzymes in the liver [2][3][4]. However, they can still interact with each other through various pathways, such as competition for metabolic enzymes or alteration of gastric pH [1].

A study published in the Journal of Clinical Psychopharmacology found that co-administration of ibuprofen and fluoxetine did not significantly affect the pharmacokinetics of either drug [5]. However, another study published in the Journal of Pharmacy and Pharmacology found that co-administration of ibuprofen and paroxetine resulted in a significant decrease in paroxetine exposure [6].

Therefore, while there is some evidence to suggest that Advil may affect antidepressant absorption, the available information is inconclusive. It is recommended that individuals consult with their healthcare provider before taking Advil or any other medication in combination with an antidepressant.

Sources:

1. <https://www.ncbi.nlm.nih.gov/books/NBK557852/>
2. <https://www.drugpatentwatch.com/drugs/ibuprofen>
3. <https://www.drugpatentwatch.com/drugs/fluoxetine>
4. <https://www.drugpatentwatch.com/drugs/citalopram>
5. <https://journals.lww.com/psychopharmacology/Abstract/2000/03000/Pharmacokinetic_Interaction_Between_Ibuprofen.2.aspx>
6. <https://onlinelibrary.wiley.com/doi/abs/10.1111/j.2042-7158.1999.tb05231.x>