Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. When taking Lipitor, it is important to be aware of any potential interactions with other medications, including over-the-counter (OTC) painkillers.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and OTC painkillers such as aspirin, ibuprofen, or naproxen. However, it is important to note that these painkillers can increase the risk of stomach bleeding and ulcers when taken regularly, especially in older adults.

GoodRx [2] lists acetaminophen (Tylenol) as a medication that may interact with Lipitor. The combination of these medications may increase the risk of liver damage. Therefore, it is recommended to avoid taking more than 3 grams of acetaminophen per day while taking Lipitor.

Drugs.com [3] also notes the potential interaction between Lipitor and acetaminophen, and recommends monitoring liver function if these medications are taken together. Additionally, it is important to talk to a healthcare provider before taking any new medications, including OTC painkillers, while taking Lipitor.

In summary, there are no known interactions between Lipitor and OTC painkillers such as aspirin, ibuprofen, or naproxen. However, acetaminophen may interact with Lipitor and increase the risk of liver damage, so it is important to avoid taking more than 3 grams of acetaminophen per day and to monitor liver function when taking these medications together. As always, it is recommended to consult with a healthcare provider before taking any new medications while taking Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/atorvastatin/interactions
[3] https://www.drugs.com/drug-interactions/atorvastatin-with-tylenol-276-0-11-12.html