Taking ibuprofen with methotrexate may not be recommended due to potential interactions between the two medications. Methotrexate is a medication commonly used to treat conditions such as rheumatoid arthritis and psoriasis, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation.

According to the Drug Patent Watch website, ibuprofen is classified as an NSAID and is commonly used for pain relief and reducing inflammation [1]. Methotrexate, on the other hand, is an immunosuppressant and is primarily used to treat autoimmune diseases [3].

A study published in the journal "The Journal of Rheumatology" investigated the effects of ibuprofen on methotrexate levels in the body. The study found that ibuprofen can increase the blood levels of methotrexate, potentially leading to increased toxicity [2]. This suggests that taking ibuprofen with methotrexate may increase the risk of side effects associated with methotrexate, such as liver damage and decreased blood cell counts.

The National Health Service (NHS) in the UK advises caution when taking ibuprofen with methotrexate. They recommend consulting a healthcare professional or pharmacist before combining these medications to ensure that it is safe and appropriate for your specific situation [3].

It is important to note that this information is based on general knowledge about the medications and their potential interactions. It is always best to consult with a healthcare professional or pharmacist who has access to your complete medical history and can provide personalized advice based on your specific circumstances.

In conclusion, based on the provided sources, it is advisable to exercise caution when considering taking ibuprofen with methotrexate. It is recommended to consult a healthcare professional or pharmacist for personalized advice on the safety and appropriateness of combining these medications.

Sources:
[1] Drug Patent Watch: IBUPROFEN. Retrieved from https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] PubMed: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs: considerations for clinical practice. Retrieved from https://pubmed.ncbi.nlm.nih.gov/2213774/
[3] NHS: Methotrexate. Retrieved from https://www.nhs.uk/medicines/methotrexate/