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Does lipitor decrease clotting factors?



Lipitor, also known as atorvastatin, is a medication that is used to lower cholesterol levels in the body. While it is not primarily used as an anti-coagulant, there is some evidence to suggest that it may have an impact on clotting factors.

According to Drug Patent Watch [1], Lipitor works by inhibiting an enzyme called HMG-CoA reductase, which is involved in the production of cholesterol in the liver. By reducing the amount of cholesterol in the body, Lipitor can help to prevent the buildup of plaque in the arteries, which can lead to heart disease and stroke.

A study published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology [2] found that Lipitor may also have an effect on clotting factors. The study looked at the effects of atorvastatin on platelet activation and found that the medication was able to reduce platelet activation and aggregation, which are both important factors in the formation of blood clots.

Another study, published in the journal Thrombosis Research [3], also found that Lipitor may have an impact on clotting factors. The study looked at the effects of atorvastatin on blood coagulation in patients with hyperlipidemia and found that the medication was able to reduce levels of several clotting factors, including fibrinogen and factor VII.

While these studies suggest that Lipitor may have an impact on clotting factors, it is important to note that the medication is not primarily used as an anti-coagulant. If you are taking Lipitor or any other medication, it is important to talk to your doctor about any concerns you may have regarding its effects on your health.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ahajournals.org/doi/full/10.1161/01.atv.0000151647.14923.ec
[3] https://pubmed.ncbi.nlm.nih.gov/15569822/



Follow-up:   How does Lipitor affect clotting factors? Are there any side effects of Lipitor on clotting factors? Can Lipitor be used to treat clotting disorders?





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