Methotrexate is a medication that has been used for over 60 years to treat a variety of conditions, including cancer, autoimmune diseases, and inflammatory conditions. While it is generally considered safe and effective, there are concerns about its long-term use in children.

According to Drug Patent Watch [1], methotrexate has been approved by the FDA for the treatment of a variety of conditions in both adults and children, including cancer, psoriasis, and rheumatoid arthritis. The drug is available in a variety of forms, including oral tablets, injectable solutions, and topical creams.

A study published in the Journal of Pediatric Pharmacology and Therapeutics [2] found that methotrexate is generally well-tolerated in children with inflammatory conditions such as juvenile idiopathic arthritis. However, the study also noted that long-term use of the drug can be associated with a variety of side effects, including liver damage, bone marrow suppression, and an increased risk of infections.

Another study published in the journal Pediatric Rheumatology [3] found that methotrexate can be an effective treatment for children with juvenile idiopathic arthritis, but that careful monitoring is necessary to ensure that the drug is not causing any harmful side effects. The study also noted that methotrexate should not be used in children with certain medical conditions, such as liver disease or immunodeficiency disorders.

In conclusion, while methotrexate can be an effective treatment for a variety of conditions in children, its long-term use can be associated with a variety of side effects. As with any medication, it is important to carefully weigh the potential benefits against the potential risks before starting treatment, and to closely monitor children who are taking the drug to ensure that it is not causing any harmful side effects.

Sources:

[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153332/
[3] https://pubmed.ncbi.nlm.nih.gov/19714630/