Lipitor, also known as atorvastatin, is a commonly prescribed medication used to lower cholesterol levels in the blood. However, some patients may experience side effects or may not respond well to statin therapy. In such cases, there are non-statin options available to replace Lipitor.

According to Drug Patent Watch [1], there are several medications that can be used as alternatives to Lipitor. These include Zetia (ezetimibe), Welchol (colesevelam), and Repatha (evolocumab). Zetia works by blocking the absorption of cholesterol in the intestines, while Welchol binds to bile acids in the intestines, preventing their reabsorption. Repatha is a newer medication that works by blocking a protein in the liver that interferes with the body's ability to remove LDL cholesterol from the blood.

GoodRx [2] also suggests several non-statin options for lowering cholesterol levels. These include fibrates such as Lopid (gemfibrozil) and Tricor (fenofibrate), niacin (vitamin B3), and omega-3 fatty acids. Fibrates work by reducing the production of triglycerides, a type of fat found in the blood, while niacin can lower LDL cholesterol and increase HDL cholesterol. Omega-3 fatty acids, found in fish oil supplements, can also help lower triglycerides and LDL cholesterol.

The British Heart Foundation [3] recommends lifestyle changes such as a healthy diet, regular exercise, and weight loss as the first line of treatment for high cholesterol. However, they also suggest that some patients may benefit from non-statin medications such as fibrates, bile acid sequestrants, and ezetimibe.

In conclusion, there are several non-statin options available to replace Lipitor for patients who cannot tolerate or do not respond well to statin therapy. These include medications such as Zetia, Welchol, and Repatha, as well as fibrates, niacin, and omega-3 fatty acids. However, it is important to consult with a healthcare provider to determine the best course of treatment based on individual needs and medical history.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.goodrx.com/conditions/high-cholesterol/statins-alternatives-medications-for-lowering-high-cholesterol
[3] https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/cholesterol-lowering-alternatives