Advil is a popular over-the-counter medication used to relieve pain and inflammation. It contains the active ingredient ibuprofen, which belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) [1]. While Advil is generally considered safe, it can cause negative interactions in some cases.

According to Drug Patent Watch [1], Advil can interact with several medications, including aspirin, corticosteroids, and blood thinners. Taking Advil with aspirin can increase the risk of stomach bleeding, while combining it with corticosteroids can increase the risk of gastrointestinal side effects. Blood thinners can also interact with Advil, increasing the risk of bleeding.

Additionally, a study published in the National Center for Biotechnology Information [2] found that NSAIDs like Advil can increase the risk of cardiovascular events, such as heart attack and stroke, especially in people with a history of heart disease. The study also found that long-term use of NSAIDs can increase the risk of gastrointestinal side effects, such as ulcers and bleeding.

Medical News Today [3] also notes that Advil can cause negative interactions with alcohol and certain medical conditions, such as asthma, kidney disease, and high blood pressure. People with these conditions should talk to their doctor before taking Advil.

In conclusion, while Advil is generally considered safe, it can cause negative interactions with certain medications and medical conditions. People should talk to their doctor before taking Advil if they have a history of heart disease, gastrointestinal problems, kidney disease, high blood pressure, or if they are taking other medications. It is also important to follow the recommended dosage and not to take Advil with alcohol.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508078/
[3] https://www.medicalnewstoday.com/articles/161071