The question at hand is whether probiotic use alters Lipitor's cholesterol-lowering effect. After reviewing the available information, there is no definitive answer to this question. However, the sources provided do offer some insight into the relationship between probiotics and cholesterol management.

Firstly, Lipitor, also known as atorvastatin, is a statin medication used to lower cholesterol levels [${1}]. Probiotics, on the other hand, are live bacteria and yeasts that are beneficial for health, especially the digestive system [${2}]. The National Center for Complementary and Integrative Health (NCCIH) states that some studies suggest probiotics may help lower cholesterol levels [${2}].

A study published in the journal Circulation Research found that certain strains of probiotics could help lower cholesterol levels [${3}]. However, this study did not specifically investigate the interaction between probiotics and Lipitor.

Therefore, while probiotics may have a cholesterol-lowering effect, there is no concrete evidence to suggest that they interfere with or enhance Lipitor's cholesterol-lowering effect. It is recommended that individuals consult with their healthcare provider before starting any new supplements or medications, including probiotics, to ensure they do not interact negatively with any current medications.

Sources:

[1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] <https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know>
[3] <https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.312782>