Based on the information provided, it is possible for mixing Advil (ibuprofen) with antidepressants to cause harm. According to the National Health Service (NHS) of the UK, certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), can interact with other medications and substances, potentially leading to serious side effects [${2}].
Although the NHS page does not specifically mention Advil as an example of a medication that can interact with antidepressants, it does warn that combining antidepressants with other drugs that affect serotonin levels can result in serotonin syndrome, a potentially life-threatening condition [${2}]. Ibuprofen, the active ingredient in Advil, may increase serotonin levels in the brain, which could potentially interact with antidepressants and contribute to serotonin syndrome [${1}].
It is important to note that not all antidepressants and medications will interact negatively. However, it is crucial to consult a healthcare professional or pharmacist before combining any medications, including over-the-counter drugs like Advil, with antidepressants [${2}].
In summary, while the available information does not explicitly state that mixing Advil and antidepressants can cause harm, it does suggest that combining antidepressants with other drugs that affect serotonin levels can be dangerous. As ibuprofen may increase serotonin levels, it is possible that combining Advil with antidepressants could lead to adverse effects. It is essential to consult a healthcare professional before combining any medications.
Sources:
* [Advil Patent Watch](https://www.drugpatentwatch.com/p/tradename/ADVIL)
* [NHS: Antidepressants: Considerations](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/)
* [NIAAA: Harmful Interactions: Mixing Alcohol with Medications](https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/harmful-interactions-mixing-alcohol-with-medicines)