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In what ways does ozempic influence satiety regulation?

See the DrugPatentWatch profile for ozempic

Ozempic (generic name: semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist, used primarily for the treatment of type 2 diabetes. It works by mimicking the functions of natural GLP-1 hormones in the body, which include regulating blood sugar levels, slowing down digestion, and promoting satiety or the feeling of fullness [1].

In terms of satiety regulation, Ozempic influences it in several ways:

1. Delaying Gastric Emptying: Ozempic slows down the rate at which the stomach empties after eating. This leads to a more gradual absorption of glucose into the bloodstream, which helps to regulate blood sugar levels. Additionally, this delayed gastric emptying contributes to a prolonged feeling of fullness, reducing the desire to eat [2].

2. Increasing GLP-1 Levels: Ozempic binds to GLP-1 receptors in the brain, leading to an increase in GLP-1 levels. This increase in GLP-1 levels has been associated with reduced food intake and body weight [3].

3. Reducing Ghrelin Levels: Ghrelin is often referred to as the "hunger hormone" because it stimulates appetite. Ozempic has been shown to reduce ghrelin levels, further contributing to the feeling of fullness and reduced food intake [4].

In conclusion, Ozempic influences satiety regulation by delaying gastric emptying, increasing GLP-1 levels, and reducing ghrelin levels. These effects can contribute to weight loss and improved blood sugar control in individuals with type 2 diabetes.

Sources:
[1] "Ozempic (semaglutide) injection, for subcutaneous use." DailyMed, U.S. National Library of Medicine, 1 Jan. 2022, [dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=48d230e1-6a8e-4e1f-a7d7-67b8a8a2b88b&type=display].
[2] "Semaglutide." DrugPatentWatch, [www.drugpatentwatch.com/drugs/semaglutide].
[3] "Semaglutide for obesity." The Lancet Diabetes & Endocrinology, vol. 9, no. 1, 2021, pp. 11-12., doi:10.1016/s2213-8587(20)30443-4.
[4] "Semaglutide for the treatment of obesity." The Lancet, vol. 397, no. 10291, 2021, pp. 2530-2531., doi:10.1016/s0140-6736(21)01444-4.


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