Combining Tylenol (acetaminophen) and Advil (ibuprofen) may be harmful and should only be done under the guidance of a healthcare professional. Both medications are pain relievers, but they work differently in the body. Tylenol is an analgesic that works on the central nervous system, while Advil is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation.

Taking these medications together may increase the risk of side effects such as stomach ulcers, gastrointestinal bleeding, and kidney damage [2]. In addition, taking more than the recommended dose of either medication can lead to liver damage from Tylenol and stomach bleeding from Advil [3].

It is important to note that some prescription medications may contain either Tylenol or Advil, and taking additional doses of these medications could lead to an overdose [1]. Patients should always consult with their healthcare provider before combining medications or taking more than the recommended dose.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/TYLENOL
[2] https://www.goodrx.com/classes/nsaids/is-it-safe-to-take-tylenol-acetaminophen-with-advil-or-motrin-ibuprofen
[3] https://www.healthline.com/health/acetaminophen-and-ibuprofen