Acetaminophen and Lipitor are two commonly used medications that have different mechanisms of action and are prescribed for different purposes. Acetaminophen is a pain reliever and fever reducer, while Lipitor is a medication used to lower cholesterol levels in the blood.

There is limited information available on how acetaminophen affects Lipitor's effectiveness. However, it is important to note that both drugs can have potential side effects, and it is essential to take them as prescribed by a healthcare provider.

According to a study published in Circulation, there is evidence that suggests that taking high doses of acetaminophen may increase the risk of cardiovascular events, such as heart attack and stroke [3]. This is important to consider for patients who are taking Lipitor to lower their cholesterol levels, as high cholesterol is a risk factor for cardiovascular disease. Therefore, it is recommended to avoid taking high doses of acetaminophen while taking Lipitor.

Additionally, according to Drug Patent Watch, there are no known drug interactions between acetaminophen and Lipitor [1]. However, it is still essential to consult with a healthcare provider before taking any medications together to ensure their safety and effectiveness.

In summary, while there is limited information available on how acetaminophen affects Lipitor's effectiveness, it is recommended to avoid taking high doses of acetaminophen while taking Lipitor due to potential cardiovascular risks associated with acetaminophen. As always, it is essential to consult with a healthcare provider before taking any medications together to ensure their safety and effectiveness.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ACETAMINOPHEN
[2] https://www.ncbi.nlm.nih.gov/books/NBK548162/
[3] https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056015