Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the body. It works by blocking the production of cholesterol in the liver, which in turn reduces the amount of cholesterol in the bloodstream [1]. On the other hand, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. It works by blocking the production of prostaglandins, which are chemicals that cause inflammation and pain in the body [2].

There is no evidence to suggest that ibuprofen affects cholesterol levels in the body. However, it is important to note that ibuprofen can increase the risk of heart failure in people with underlying heart conditions. This is because ibuprofen can cause the body to retain fluid, which can put extra strain on the heart [2].

It is important to be cautious when taking both Lipitor and ibuprofen together, as they can interact with each other. Ibuprofen can increase the risk of side effects from Lipitor, such as muscle pain and weakness. This is because ibuprofen can increase the concentration of Lipitor in the bloodstream, which can make it more difficult for the body to metabolize the drug [3].

In conclusion, Lipitor and ibuprofen have different mechanisms of action and do not affect cholesterol levels in the same way. However, it is important to be aware of the potential interactions between these two medications and to talk to a healthcare provider before taking them together.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.bhf.org.uk/informationsupport/heart-matters-magazine/news/behind-the-headlines/ibuprofen-and-heart-failure
[3] https://www.verywellhealth.com/statin-side-effects-and-drug-interactions-698202