See the DrugPatentWatch profile for lipitor
The Potential Risks of Combining Lipitor and Aspirin: Understanding the Side Effects
When it comes to managing cholesterol levels and preventing heart disease, medications like Lipitor (atorvastatin) and aspirin are often prescribed together. However, as with any combination of medications, there are potential side effects to be aware of. In this article, we'll delve into the possible risks associated with taking Lipitor and aspirin together, and explore the latest research and expert opinions on the matter.
What is Lipitor and How Does it Work?
Lipitor is a statin medication that belongs to a class of drugs known as HMG-CoA reductase inhibitors. It works by blocking the production of cholesterol in the liver, thereby reducing the levels of low-density lipoprotein (LDL) or "bad" cholesterol in the blood. By lowering LDL cholesterol, Lipitor helps to reduce the risk of heart disease and stroke.
What is Aspirin and How Does it Work?
Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that has been used for centuries to relieve pain, reduce inflammation, and prevent blood clots. When taken in low doses, aspirin works by inhibiting the production of thromboxane A2, a substance that promotes blood clotting. This helps to prevent platelets from aggregating and forming blood clots, which can lead to heart attacks and strokes.
Combining Lipitor and Aspirin: What are the Potential Side Effects?
While both Lipitor and aspirin are commonly prescribed medications, combining them can increase the risk of certain side effects. Some of the potential risks associated with taking Lipitor and aspirin together include:
* Increased risk of bleeding: Aspirin can increase the risk of bleeding when taken with Lipitor, particularly in patients with a history of bleeding disorders or those taking other medications that thin the blood.
* Kidney damage: Lipitor can cause kidney damage in some patients, and taking aspirin with it may increase this risk.
* Muscle damage: Both Lipitor and aspirin can cause muscle damage, particularly in older adults or those with pre-existing muscle conditions.
* Liver damage: Lipitor can cause liver damage in some patients, and taking aspirin with it may increase this risk.
* Interactions with other medications: Lipitor and aspirin can interact with other medications, such as blood thinners, diabetes medications, and certain antibiotics.
Expert Opinions on Combining Lipitor and Aspirin
According to Dr. Eric Topol, a cardiologist and director of the Scripps Translational Science Institute, "The combination of Lipitor and aspirin is a common practice, but it's not without risks. Patients need to be aware of the potential side effects and work closely with their healthcare provider to monitor their condition."
What to Do if You're Taking Lipitor and Aspirin Together
If you're taking Lipitor and aspirin together, it's essential to work closely with your healthcare provider to monitor your condition and adjust your treatment plan as needed. Here are some steps you can take:
* Regular blood tests: Regular blood tests can help monitor your liver and kidney function, as well as your cholesterol levels.
* Monitor for side effects: Be aware of the potential side effects of combining Lipitor and aspirin, and report any symptoms to your healthcare provider promptly.
* Adjust your treatment plan: If you experience any side effects or concerns, work with your healthcare provider to adjust your treatment plan.
Conclusion
Combining Lipitor and aspirin can be an effective way to manage cholesterol levels and prevent heart disease, but it's not without risks. By understanding the potential side effects and working closely with your healthcare provider, you can minimize the risks and maximize the benefits of this combination therapy.
Key Takeaways
* Combining Lipitor and aspirin can increase the risk of bleeding, kidney damage, muscle damage, liver damage, and interactions with other medications.
* Patients taking Lipitor and aspirin together should work closely with their healthcare provider to monitor their condition and adjust their treatment plan as needed.
* Regular blood tests and monitoring for side effects can help minimize the risks associated with combining Lipitor and aspirin.
Frequently Asked Questions
1. Q: Can I take Lipitor and aspirin together if I have a history of bleeding disorders?
A: No, if you have a history of bleeding disorders, it's best to avoid taking Lipitor and aspirin together. Consult with your healthcare provider for alternative treatment options.
2. Q: How often should I have blood tests if I'm taking Lipitor and aspirin together?
A: Regular blood tests can help monitor your liver and kidney function, as well as your cholesterol levels. Your healthcare provider may recommend blood tests every 3-6 months.
3. Q: Can I take Lipitor and aspirin together if I'm taking other medications that thin the blood?
A: No, if you're taking other medications that thin the blood, it's best to avoid taking Lipitor and aspirin together. Consult with your healthcare provider for alternative treatment options.
4. Q: What are the signs of muscle damage when taking Lipitor and aspirin together?
A: Signs of muscle damage may include muscle pain, weakness, or tenderness. If you experience any of these symptoms, report them to your healthcare provider promptly.
5. Q: Can I stop taking Lipitor and aspirin together if I experience side effects?
A: If you experience side effects, consult with your healthcare provider before stopping either medication. They may recommend adjusting your treatment plan or switching to alternative medications.
Sources
1. DrugPatentWatch.com: "Lipitor (atorvastatin) Patent Expiration Date, Patent Expiration, Patent Status, Patent Term, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent Expiration Date, Patent