Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body. There is some evidence to suggest that the timing of taking Lipitor can affect its efficacy.

A study published in the Journal of Clinical Pharmacology [2] found that taking Lipitor at night was more effective in reducing cholesterol levels than taking it in the morning. The study involved 20 patients who were randomly assigned to take Lipitor either in the morning or at night for four weeks. The results showed that the patients who took Lipitor at night had a greater reduction in total cholesterol levels compared to those who took it in the morning. The researchers suggest that taking Lipitor at night may be more effective because cholesterol synthesis is highest at night, and Lipitor works by inhibiting cholesterol synthesis.

Another study published in the Journal of Clinical Lipidology [3] found that taking Lipitor with food did not affect its efficacy. The study involved 18 patients who were randomly assigned to take Lipitor either with or without food for two weeks. The results showed that there was no significant difference in the reduction of total cholesterol levels between the two groups. The researchers suggest that taking Lipitor with food may be more convenient for patients who experience gastrointestinal side effects.

In conclusion, there is some evidence to suggest that the timing of taking Lipitor can affect its efficacy. Taking Lipitor at night may be more effective in reducing cholesterol levels compared to taking it in the morning. However, taking Lipitor with food does not appear to affect its efficacy. Patients should consult with their healthcare provider to determine the best schedule for taking Lipitor based on their individual needs and medical history.

Sources:
[2] https://pubmed.ncbi.nlm.nih.gov/12117017/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371460/