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How can lipitor affect blood pressure in hypertensive patients?



Lipitor is a brand name for the drug atorvastatin, which is commonly used to lower cholesterol levels in patients with high cholesterol. According to Drug Patent Watch [1], Lipitor works by inhibiting an enzyme in the liver that is responsible for producing cholesterol. However, it is unclear how Lipitor affects blood pressure in hypertensive patients.

A study published in the Journal of Clinical Hypertension [2] investigated the effects of atorvastatin on blood pressure in hypertensive patients. The study found that atorvastatin did not have a significant effect on blood pressure in these patients. The researchers concluded that atorvastatin may not be an effective treatment for hypertension.

However, a press release from Pfizer [3] suggests that adding Lipitor early to effective blood pressure treatment can provide a significant reduction in heart attacks or deaths from heart attacks over five years. The press release cites a study that found that adding Lipitor to blood pressure treatment reduced the risk of heart attack or death from heart attack by 36% compared to blood pressure treatment alone.

In summary, while there is some evidence to suggest that Lipitor may not have a significant effect on blood pressure in hypertensive patients [2], there is also evidence to suggest that adding Lipitor to effective blood pressure treatment can reduce the risk of heart attack or death from heart attack [3]. However, it is important to note that Lipitor should only be used under the guidance of a healthcare professional and should not be used as a sole treatment for hypertension.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/21881597/
[3] https://www.pfizer.com/news/press-release/press-release-detail/adding_lipitor_early_to_effective_blood_pressure_treatment_provided_a_significant_reduction_in_heart_attacks_or_deaths_from_heart_attacks_over_five_years.



Follow-up:   Does Lipitor lower blood pressure in hypertensive patients? What is the recommended Lipitor dosage for hypertension? Are there any side effects of Lipitor on blood pressure?





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