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What are the side effects of combining advil and tylenol?

Combining Advil (ibuprofen) and Tylenol (acetaminophen) can be an effective way to manage pain and fever. However, it is important to be aware of the potential side effects of this combination. Both Advil and Tylenol are over-the-counter medications commonly used to relieve pain and reduce fever. They belong to different drug classes and work in different ways to alleviate symptoms.

Advil is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing inflammation and blocking the production of certain chemicals in the body that cause pain and fever. Tylenol, on the other hand, is an analgesic and antipyretic that works by inhibiting the production of prostaglandins, which are substances that cause pain and fever.

When used together, Advil and Tylenol can provide a more potent pain relief effect than when used alone. This combination is often recommended by healthcare professionals for managing moderate to severe pain, such as postoperative pain or dental pain [2]. However, it is essential to follow the recommended dosages and consult a healthcare professional before combining these medications.

While combining Advil and Tylenol can be effective, it is important to note that there are potential side effects associated with their use. Both medications can cause gastrointestinal issues such as stomach upset, indigestion, and even stomach ulcers, especially when used at high doses or for a prolonged period [1]. Additionally, Advil can increase the risk of bleeding and may affect kidney function, especially in individuals with pre-existing kidney problems. Tylenol, when taken in excessive doses, can cause liver damage [3].

It is also worth mentioning that both medications can interact with other drugs and medical conditions. It is crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions and adverse effects.

In conclusion, combining Advil and Tylenol can provide effective pain relief and fever reduction. However, it is important to use these medications responsibly and follow the recommended dosages. It is always advisable to consult a healthcare professional before combining medications and to be aware of the potential side effects and interactions. If you experience any adverse effects, it is recommended to seek medical attention promptly.

[1] Drug Patent Watch. (n.d.). Advil. Retrieved from
[2] Healthline. (2021, April 13). Acetaminophen and Ibuprofen: Can You Take Them Together? Retrieved from
[3] Medical News Today. (2020, June 10). Acetaminophen and ibuprofen: How do they work? Retrieved from

Follow-up:   Can you take Advil and Tylenol together safely? Are there any adverse reactions when mixing Advil and Tylenol? What are the potential risks of combining Advil with Tylenol?

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