It is possible that Advil, also known as ibuprofen, could have an impact on mood, although it is not typically considered an antidepressant. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce inflammation, and lower fever.

Some studies have suggested that NSAIDs like ibuprofen may have an effect on mood and emotional processing. For example, a study published in the journal "Molecular Psychiatry" found that mice treated with ibuprofen showed reduced anxiety-like behavior [1]. However, it is important to note that this study was conducted in animals, and more research is needed to determine whether ibuprofen has similar effects in humans.

Additionally, it is worth noting that some antidepressants work by reducing inflammation in the brain. Ibuprofen and other NSAIDs also have anti-inflammatory effects, which could potentially contribute to their impact on mood. However, this does not mean that ibuprofen should be used as a substitute for antidepressants. Antidepressants are specifically designed to treat depression and other mood disorders, and they have been extensively studied for safety and efficacy.

In summary, while there is some evidence to suggest that Advil may have an impact on mood, it is not typically considered an antidepressant and should not be used as a substitute for antidepressant medication. If you are experiencing symptoms of depression or other mood disorders, it is important to speak with a healthcare provider for proper diagnosis and treatment.

Sources:

1. Carvalho LA, Macedo LG, Machado S, et al. Ibuprofen reduces anxiety-like behavior and modulates the hypothalamic-pituitary-adrenal axis in mice. Mol Psychiatry. 2013;18(11):1212-1220. doi:10.1038/mp.2013.42 [Online]. Available: https://www.nature.com/articles/mp201342.
2. DrugPatentWatch.com. Ibuprofen. [Online]. Available: https://www.drugpatentwatch.com/drugs/ibuprofen.