Yes, Tigecycline can inhibit Gram-positive bacteria. Tigecycline is a broad-spectrum antibiotic that is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria [1]. It is a glycylcycline antibiotic, which is a class of antibiotics that are structurally similar to tetracyclines but have improved antibacterial activity and a broader spectrum of activity [1].

Tigecycline has been shown to be effective against a variety of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) [1]. These bacteria can cause serious and life-threatening infections, and tigecycline is often used as a last-line treatment option for these infections [1].

It is important to note that the development and use of antibiotics, such as tigecycline, must be carefully managed to prevent the emergence of antibiotic resistance [2]. Antibiotic resistance is a growing concern, and the misuse and overuse of antibiotics can lead to the development of bacteria that are resistant to treatment [2].

In summary, Tigecycline is a broad-spectrum antibiotic that is effective against a wide range of bacteria, including Gram-positive bacteria such as MRSA and VRE. However, the use of antibiotics must be carefully managed to prevent the emergence of antibiotic resistance.

Sources:

* [1] "Tigecycline: a review of its use in the treatment of intra-abdominal infections." Expert Review of Anti-infective Therapy. <https://www.tandfonline.com/doi/full/10.1586/14787210.8.5.527>
* [2] "Antibiotic resistance threats in the United States, 2019." Centers for Disease Control and Prevention. <https://www.cdc.gov/drugresistance/biggest-threats.html>
* DrugPatentWatch.com - A website that provides information on drug patents, including tigecycline. <https://www.drugpatentwatch.com/drugs/tigecycline>