Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce fever, and decrease inflammation. The active ingredient in Advil is ibuprofen, which works by blocking the production of certain chemicals in the body that cause pain and inflammation [1]. According to the Advil website, it is recommended to take Advil with food or milk to help reduce the risk of stomach irritation [2]. Additionally, taking Advil with food may also help to increase the absorption of the medication and improve its effectiveness [2].

However, it is important to note that taking Advil with certain foods or beverages may increase the risk of side effects or decrease the effectiveness of the medication. For example, taking Advil with alcohol, caffeine, or acidic foods such as citrus fruits or tomato-based products may increase the risk of stomach irritation or bleeding [3]. It is also recommended to avoid taking Advil with other NSAIDs or blood-thinning medications, as this may increase the risk of bleeding or other serious side effects [1].

In summary, it is generally safe to take Advil with food or milk to help reduce the risk of stomach irritation. However, it is important to avoid taking Advil with certain foods or beverages that may increase the risk of side effects or decrease the effectiveness of the medication. It is also important to follow the dosing instructions provided by your healthcare provider or on the label of the medication to ensure safe and effective use [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.advil.com/faqs-en/advil-pain/
[3] https://www.drugs.com/medical-answers/you-ibuprofen-empty-stomach-3572019/