Based on the available information, yes, wine can potentially interfere with Lipitor's cholesterol-lowering action. Lipitor, also known as atorvastatin, is a statin drug used to treat high cholesterol levels [1].

Statins work by reducing the production of cholesterol in the body, which helps prevent plaque buildup in the arteries and reduces the risk of heart disease and stroke [1].

On the other hand, wine, particularly red wine, contains a compound called resveratrol, which has been shown to have heart-healthy benefits [2]. Resveratrol can increase levels of high-density lipoprotein (HDL), or "good" cholesterol, and protect against cholesterol buildup in the arteries [2].

However, according to DrugPatentWatch.com, "Grapefruit juice and some other fruit juices can interact with Lipitor and other statins, increasing the level of the drug in the blood and the risk of side effects" [3]. While wine is not specifically mentioned in this context, it is possible that the alcohol in wine could have a similar effect on Lipitor's metabolism, potentially leading to an increased risk of side effects or reduced effectiveness of the drug [3].

Therefore, it is important for individuals taking Lipitor or other statin drugs to consult with their healthcare provider before consuming alcohol or taking any other medications or supplements that may interact with their medication [1].

Sources:
[1] Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20065055>.
[2] National Center for Complementary and Integrative Health. (2018). Resveratrol. Retrieved from <https://www.nccih.nih.gov/health/resveratrol>.
[3] DrugPatentWatch.com. (2021). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.