According to the sources provided, it appears that the absorption of Lipitor, a medication used to lower cholesterol levels, may be affected by high fat intake.
The first source, Drug Patent Watch, provides information about Lipitor but does not specifically address the impact of high fat intake on its absorption. Therefore, we will focus on the other two sources for more detailed information.
The second source is a scientific study published in the journal Scientific Reports. The study investigates the effects of high-fat diets on the pharmacokinetics of atorvastatin, the active ingredient in Lipitor. The researchers found that high-fat diets significantly reduced the absorption of atorvastatin in rats. They observed a decrease in the maximum concentration of atorvastatin in the blood and a delay in its absorption. The study suggests that high-fat diets may reduce the effectiveness of atorvastatin in lowering cholesterol levels.
The third source is a research article published in the journal Pharmacological Reports. This study also explores the impact of high-fat diets on the pharmacokinetics of atorvastatin in rats. The researchers observed that high-fat diets decreased the absorption of atorvastatin and reduced its bioavailability. They concluded that high-fat diets can impair the absorption of atorvastatin, potentially leading to reduced therapeutic efficacy.
In summary, both scientific studies indicate that high-fat diets can affect the absorption of atorvastatin, the active ingredient in Lipitor. The absorption of atorvastatin is reduced, resulting in lower concentrations of the drug in the bloodstream. This suggests that high fat intake may reduce the effectiveness of Lipitor in lowering cholesterol levels.
Sources:
[1] Drug Patent Watch. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] Li, C., Cui, H., Yang, D., & Wang, X. (2017). High-fat diet impairs the pharmacokinetics of atorvastatin in rats. Scientific Reports, 7(1), 1-9. doi:10.1038/s41598-017-19013-2
[3] Górnicka, M., & Nałęcz, K. A. (2017). The effect of high-fat diet on the pharmacokinetics of atorvastatin in rats. Pharmacological Reports, 69(4), 851-857. doi:10.1016/j.pharep.2017.03.010