Lipitor is a brand name for atorvastatin, a drug that is used to lower cholesterol levels in the blood. According to the Mayo Clinic [2], statins, including Lipitor, are generally safe and well-tolerated by most people. However, like any medication, Lipitor can cause side effects. The most common side effects of Lipitor include muscle pain, weakness, and tenderness, which can sometimes lead to a condition called rhabdomyolysis, a serious and potentially life-threatening condition that can cause kidney damage.

There is no evidence to suggest that exercise can worsen the side effects of Lipitor [2]. In fact, exercise is generally recommended for people with high cholesterol levels, as it can help to improve cholesterol levels and reduce the risk of heart disease. However, it is important to talk to your doctor before starting any new exercise program, especially if you are taking Lipitor or any other medication.

According to a study published in the Journal of Clinical Lipidology [3], exercise can actually help to improve the effectiveness of statins, including Lipitor. The study found that people who took statins and exercised regularly had lower cholesterol levels than those who only took statins. The study also found that exercise helped to reduce the risk of muscle pain and weakness associated with statin use.

In conclusion, there is no evidence to suggest that exercise can worsen the side effects of Lipitor. In fact, exercise can be beneficial for people taking Lipitor, as it can help to improve cholesterol levels and reduce the risk of heart disease. However, it is important to talk to your doctor before starting any new exercise program, especially if you are taking Lipitor or any other medication.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463373/