According to the sources provided, there is limited information available on the exact number of active clinical trials in the United States specifically for the treatment of cancer with olaparib. However, we can gather some information from the sources you provided.
The first source, DrugPatentWatch, provides information on the patent status and expiration of drugs, including olaparib. While it does not provide specific information about clinical trials, it can be a useful resource for understanding the market exclusivity of the drug.
The second source, ClinicalTrials.gov, is a comprehensive database of clinical trials conducted worldwide. The specific trial you mentioned, NCT03641755, is a Phase 3 trial evaluating the efficacy and safety of olaparib in combination with other drugs for the treatment of advanced ovarian cancer. This trial is currently active and recruiting participants. While this source does not provide an exact number of trials, it is a valuable resource for finding ongoing clinical trials.
The third source, the National Cancer Institute's Clinical Trials Search, provides a search tool for finding cancer clinical trials. The specific trial you mentioned, NCI-2018-02375, is a Phase 1/2 trial evaluating the safety and efficacy of olaparib in combination with other drugs for the treatment of solid tumors, including ovarian cancer. Again, this trial is active and recruiting participants. Like the previous source, this database does not provide an exact number of trials but is helpful for finding relevant ongoing trials.
Based on the information provided, it is difficult to determine the exact number of active clinical trials in the US for the treatment of cancer with olaparib. However, the sources you provided offer valuable information on ongoing trials and can be used to search for additional trials that may be relevant to your query.
Sources:
[1] DrugPatentWatch: https://www.drugpatentwatch.com/p/tradename/OLAPARIB
[2] ClinicalTrials.gov: https://www.clinicaltrials.gov/ct2/show/NCT03641755
[3] National Cancer Institute's Clinical Trials Search: https://www.cancer.gov/research/participate/clinical-trials-search/v?id=NCI-2018-02375&loc=0&ni=10&pn=149&rl=1