Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, there is no indication that Lipitor reacts differently when taken with low-fat meals compared to high-fat meals.

However, it is recommended to take Lipitor with or without food at the same time every day to maintain a consistent level of the medication in the bloodstream [2]. Additionally, consuming grapefruit or grapefruit juice while taking Lipitor can increase the risk of side effects [3].

It is important to follow the instructions provided by the prescribing healthcare provider and to inform them of any changes in diet or other medications being taken to avoid any potential interactions or adverse effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details
[3] https://www.medicalnewstoday.com/articles/atorvastatin-oral-tablet