Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. When taking Lipitor, it is important to be aware of potential interactions with supplements. According to SingleCare [2], there are several supplements that can interact with Lipitor and increase the risk of side effects. These supplements include St. John's Wort, red yeast rice, and grapefruit juice. St. John's Wort can reduce the effectiveness of Lipitor, while red yeast rice can increase the risk of muscle pain and liver damage. Grapefruit juice can increase the concentration of Lipitor in the blood, which can increase the risk of side effects.

In addition to supplement interactions, there are also potential risks associated with taking Lipitor. According to Mayo Clinic [3], common side effects of Lipitor include muscle pain and weakness, liver damage, and digestive problems. In rare cases, Lipitor can also cause a serious muscle condition called rhabdomyolysis, which can lead to kidney damage and even death.

It is important to talk to your doctor before taking any supplements while on Lipitor. They can help you determine which supplements are safe to take and which ones to avoid. They can also monitor you for any potential side effects or interactions.

Sources:
[2] https://www.singlecare.com/blog/atorvastatin-interactions/
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013