There is currently no definitive scientific consensus on whether probiotics directly affect the efficacy of Lipitor (atorvastatin), a medication used to treat high cholesterol levels. Some studies suggest that certain probiotics may help lower cholesterol levels [1], which could potentially have an impact on Lipitor's effectiveness as it is also used to lower cholesterol. However, these studies do not specifically address the interaction between probiotics and Lipitor.

It is important to note that drug interactions can be complex and may depend on various factors, including the specific probiotic strain, dosage, and individual patient characteristics. Therefore, it is always recommended to consult with a healthcare provider before starting any new supplements or medications, including probiotics, while taking Lipitor.

In summary, while some probiotics may have a cholesterol-lowering effect, there is no direct evidence to suggest that they interact with or affect Lipitor's efficacy. Consult with a healthcare provider for personalized advice.

Sources:
[1] "Probiotics for the Prevention and Treatment of Disease." National Center for Complementary and Integrative Health (NCCIH), U.S. Department of Health and Human Services, www.nccih.nih.gov/health/probiotics/introduction.htm.
[2] "Atorvastatin (Oral Route)." Mayo Clinic, Mayo Foundation for Medical Education and Research, 1 Jan. 2022, www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063065.
[3] "Lipitor (Atorvastatin) Drug Patent Expiration Dates." DrugPatentWatch, drugpatentwatch.com/lipitor-atorvastatin.