Based on the available information, there is no explicit evidence suggesting that shrimp scampi directly affects the effectiveness of Lipitor, a medication used to treat high cholesterol levels. Lipitor, also known as atorvastatin, works by reducing the amount of cholesterol produced by the body [1].

Shrimp scampi is a dish typically made with shrimp, butter, garlic, and various seasonings. While shrimp is a good source of astaxanthin, a carotenoid with antioxidant properties [3], there is no evidence to suggest that this has any interaction with Lipitor's effectiveness.

However, it's important to note that some ingredients in shrimp scampi, such as butter and garlic, can contribute to a higher fat and calorie intake, which may impact overall heart health if consumed in excess. High-fat meals can potentially affect the absorption and metabolism of Lipitor, but this is not specific to shrimp scampi [2].

In conclusion, while shrimp scampi does not directly affect Lipitor's effectiveness, maintaining a balanced diet and lifestyle is crucial for overall heart health and the effectiveness of cholesterol-lowering medications. Always consult with a healthcare provider for personalized advice.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.medicalnewstoday.com/articles/315947
[3] https://www.verywellhealth.com/astaxanthin-uses-side-effects-precautions-storage-7507313